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  • br Conclusion br An electrical network based sensor modeling

    2020-08-12


    4. Conclusion
    An electrical network-based sensor modeling approach using pas-sive components is reported in this paper, which is an innovative concept for predicting gene attributes. The results are made by simu-lation using MATLAB (version R2009b). The sensor achieves MCC value of 0.784 and accuracy values of 89.55%, with 87.06% and 95.42% for True Positive and True Negative class respectively. The proposed sensor is expected to be helpful for selection of cancerous and non-cancerous genes used in biophysical and structural biology studies. The Predictive ability of the sensor is confirmed by analyzing correlation of the elec-trical responses with gene features. This modeling approach is re-stricted up to certain size of genes. Furthermore, it is also unable to identify genes which are undefined by amino SP600125 primary structure.
    In future, the proposed sensor design can also be extended to other genetic disease prediction, which will be beneficial in pharmacoge-nomics and forensic studies. Finally, the gene classifier system relia-bility and robustness needs further improvement for more accurate and detailed prediction of gene attributes.
    Acknowledgements
    The author T. Roy would like to thank DST, Science and Engineering Research Board, India (EEQ/2017/000293), for funding the research work. 
    Competing interests
    No competing interest.
    Funding
    DST, Science and Engineering Research Board, Govt. of India.
    Ethical approval
    Not required.
    References
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    Marshall, R., 2010b. Modeling secondary structures and secondary structure linkages of protein sequences. In: Proc. IEEE International Conference on Systems Man and Cybernetics. pp. 2995–3000.
    Matthews, B.W., 1975. Comparison of the predicted and observed secondary structure of T4 phage lysozyme. Biochim. Biophys. Acta Prot. Struct. 405, 442–445. McClellan, D.A., 2012. Detecting molecular selection on single amino acid replacements.
    Mutation and expression of the p51 gene in human lung cancer. Neoplasia 1, 71–79.
    69 Accepted Manuscript
    Title: Analysis of clinicopathological features and prognosis of 1315 cases in colorectal cancer located at different anatomical subsites
    Authors: Zhen Feng, Xiaomeng Shi, Qianshi Zhang, Xinsheng Zhang, Xiaomeng Li, Zihao Chen, Dunbo Liu, Bisheng Sun, Yunfei Zuo, Shuangyi Ren
    This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before Endonucleases is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
    Title: Analysis of clinicopathological features and prognosis of 1315 cases in colorectal cancer located at different anatomical subsites
    Author names and affiliations:
    Zhen Feng1, Xiaomeng Shi1, Qianshi Zhang1, Xinsheng Zhang1, Xiaomeng Li2, Zihao Chen1, Dunbo Liu1, Bisheng Sun1, Yunfei Zuo2, Shuangyi Ren1
    1, Department of Gastrointestinal Surgery, Second Affiliated Hospital of Dalian Medical University, NO. 467, Zhongshan Road, DaLian, 116023, China
    2, Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, NO. 9, Lvshun South Road, DaLian, 116044, China Zhen Feng and Xiaomeng Shi contributed equally to this paper. Yunfei Zuo and Shuangyi Ren are co- corresponding authors.
    Correspondence to: Prof. Yunfei Zuo. Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, NO. 9, Lvshun South Road, DaLian, 116044, China. Email: [email protected] Prof. Shuangyi Ren. Department of Gastrointestinal Surgery, Second Affiliated ACCEPTEDHospitalofDalianMedicalUniversity, NO. 467, Zhongshan Road, DaLian, 116023, China. Email: [email protected] Telephone number: 17709873737 Abstract
    Purpose: Compare and analyze the clinicopathological features and prognosis of 1315 patients with colorectal cancer located at different anatomical subsites.
    Methods: retrospective study was conducted to analyze the clinicopathological features and prognosis from 1315 patients with colorectal cancer who underwent surgery in the department of gastrointestinal surgery at the Second Affiliated Hospital of Dalian Medical University from January 2013 to January 2019. Among them, 287 patients were divided into the right-sided colon cancer (RCC) group; 329 patients were